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Co-hosts Cynthia Graber and Nicola Twilley serve up a brand new episode every two weeks.

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The calorie seems to be an obviousmeasurement for food. But, in fact, it took hundreds of years and thousands of experiments to nail down what exactly the calorie means, both as a measurement ofthe food itself(that is, how much energy is contained in the form of a cheeseburger) and a measurement of consumption (how much energy we cheeseburger-eating humans burn as we go about our daily lives). With assistance from nutritionist Marion Nestle, author of Why Calories Count: From science to politics , we trace the calorie's earliest history, from an obsessive-compulsive Italian who invented a special chair with which to measure everything he ate, drank, and excreted over a thirty-year period, to the French chemist who put a guinea pig in a coffee urn to measure how much heat it gave off. Then we travel to the USDA laboratories in Beltsville, Maryland, to check out the way scientists measure calories today: by putting people in tricked-out walk-in coolers and freeze-drying their feces.

IMAGE: (Left) Santorio Sanctorius's weighing chair. (Right) Lavoisier and Laplace's Ice Calorimeter (Diucênio Rangel/ Nature Education ).

While we're in Beltsville, we also learn about intriguing new USDA studies that have found that, for some foods, the calorie counts on the label are off by double-digit percentages. Following this trail, we end up at Harvard, talking to anthropologist Richard Wrangham about the ways humans have learned to change the number of calories we get from our food by cooking it. And we dive into the differences in how people process calories by visiting microbiologist Peter Turnbaugh at UCSF, who points us todramatic new research demonstrating the effectthe tiny creatures in our gut have onthe amount of calories we absorb. The University of Alberta's David Wishart offers us a glimpse of the future, in which truly personalized nutrition advice will evolve from the emerging science of how the chemicals in our bodies interact with all the different chemicals in the food we eat. And Susan Roberts, director of the energy metabolism laboratoryat the Tufts USDA nutrition center, suggests analternative unit as a replacement for the traditional calorie.

IMAGE: David Baer, Bill Rumpler, and Cynthia inside the human calorimeter at the USDA in Beltsville, Maryland.

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